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In this study using pure
2024-05-18
In this study, using pure enzyme preparations of human placental recombinant AR (hAR) and of AR isolated from bovine lens (bAR), which behave as Michaelis 2578 mg with glyceraldehyde as substrate, is shown that an apparent negative cooperativity action for glucose still occurs. We present evidence
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Here we have used transcriptome analysis of primary neonatal
2024-05-18
Here, we have used transcriptome analysis of primary neonatal rat cardiomyocytes treated with either the ETR agonist endothelin-1 or the α1-AR agonist phenylephrine to assess differences in their respective signalling networks, and further probed these differences using a panel of fluorescent resona
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br Acknowledgments and Disclosures br Introduction In mammal
2024-05-18
Acknowledgments and Disclosures Introduction In mammals, ejaculated sperm requires a finite period of residence in the female reproductive tract to become competent for fertilization (Visconti et al., 1995a, Visconti et al., 1995b). Once oocytes are matured, it is important for these cells to
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One study has demonstrated that PUFA reduced
2024-05-18
One study has demonstrated that ω-3 PUFA reduced both cholesterol and caveolin-1 (a marker of raft), thereby displacing raft-associated signaling molecules from lipid raft [36]. Additionally, DHA treatment decreased the amount of lipid raft in the cell surface and displaced several lipid raft-associ
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The AR signalling pathways play
2024-05-18
The AR signalling pathways play important roles in several physiopathological processes associated with ischaemia, inflammation, and tumourigenesis [35]. Moreover, A3AR is overexpressed in different tumour Epothilone B and seems implicated in pro- or anti-apoptotic effects [36]. In particular, activ
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br Introduction Adenosine deaminase ADA which can
2024-05-18
Introduction Adenosine deaminase (ADA), which can catalyze the conversion of AD to inosine by removing an amino group, is a key hydrolytic enzyme of purine metabolism (Conway and Cooke, 1939), and plays an important role in an amount of diseases. For example, an increase of ADA activity in serum
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br Perspectives Given the complexity of the cellular interac
2024-05-18
Perspectives Given the complexity of the cellular interactome and of protein scaffolding, further progress in revealing how individual membrane proteins, including APP and AChE, interact with each other at various levels, from cell-surface shedding to gene regulation, will clarify some intrinsic
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NSAIDs induce gastrointestinal toxicity and evoke
2024-05-18
NSAIDs induce gastrointestinal toxicity and evoke motilin receptor by decreasing the production of gastroprotective prostanoids and by redirecting the COX substrate AA into LT biosynthesis, thereby causing vasoconstriction in gastric mucosa and airways (Celotti and Laufer, 2001; Koeberle and Werz,
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The mechanism by which Gas
2024-05-18
The mechanism by which Gas6 prevents inflammation has been reported to be via inhibition of Toll-Like receptors (TLRs) signaling (Cui et al., 2016). After injury, TLRs become stimulated, leading to downstream activation of TRAF3 and TRAF6 and translocation of several transcription factors, such as I
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br Materials and methods br Results br Discussion The succes
2024-05-18
Materials and methods Results Discussion The success of CAR-T cell therapy is based on two major facts: one is that cancer cells express tumor-associated antigens (TAAs) on their surface that can be detected by the human immune system; the other is that the CAR molecules target these TAAs o
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br Concluding Remarks and Future Directions The physiologica
2024-05-18
Concluding Remarks and Future Directions The physiological significance of autophagy in neuronal function is steadily emerging. The studies discussed herein reveal that key neuronal functions, such as neurotransmitter release, pruning of dendritic spines, and behavioural outputs of neural network
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br Introduction In addition to ATP production an important
2024-05-18
Introduction In addition to ATP production, an important role of mitochondria in the pancreatic beta cell is anaplerosis, which is the net synthesis of citric IKK Inhibitor VII receptor cycle intermediates that are exported to the cytosol where they are converted to numerous other metabolites th
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br Disclaimer Statement br Acknowledgments br Introduction M
2024-05-18
Disclaimer Statement Acknowledgments Introduction Metabolic changes are a common feature of cancerous tissues. Mutations in oncogenes and tumor suppressor genes cause alterations to multiple intracellular signaling pathways that rewire tumor cell metabolism and re-engineer it to allow enhan
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Another contributor for the G M arrest in A and
2024-05-18
Another contributor for the G2/M arrest in A549 and H1299 cells might be p21WAF1/CIP1 which was up-regulated upon ovatodiolide treatment. p21WAF1/CIP1 is a common CDKs inhibitor which blocks Ridaforolimus G2/M phase progression in various types of cancer cells (Kim et al., 2015, Liberio et al., 2015
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The amino hydroxy methyl isoxazolepropionic acid AMPA recept
2024-05-18
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic AVL-292 (AMPA) receptor is also enriched in postsynaptic striatal neurons (Bernard et al., 1997, Kondo et al., 2000, Reimers et al., 2011). Its activity is subjected to the regulation by a mechanism involving phosphorylation (Lu and Roche, 2012).